CpG blocks suppression by MDSC Zoglmeier et al. Page 1 of 24 CpG blocks immune suppression by myeloid-derived suppressor cells in tumor- bearing mice
نویسندگان
چکیده
Authors Affiliations: Division of Clinical Pharmacology and Center of Integrated Protein Science Munich, Munich, Germany Financial support: This work was supported by grants from the LMUexcellent research professorship (to S.E.), the German Research Foundation: DFG En 169/7-2 and Graduiertenkolleg 1202 (to C.B. and S.E.), the excellence cluster Center for Integrated Protein Science Munich 114 (to S.E.), BayImmuNet (to C.B. and S.E.) and the Friedrich-Baur Foundation and Weigand-Gravenhorst Foundation (to C.Z). This work is part of the doctoral theses of H.B., D.N., G.W. and P.B. at the Ludwig-Maximilian University of Munich.
منابع مشابه
CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
Purpose: The Toll-like receptor (TLR) 9 ligand CpG has been used successfully for the immunotherapy of cancer. Chronic CpG application in tumor-free hosts leads, however, to the expansion of myeloidderived suppressor cells (MDSC), which can cause T-cell suppression and may thus hamper the development of an effective immune response. Here, we investigated the effect of TLR9 activation on the fun...
متن کاملCorrection: CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice.
PURPOSE The Toll-like receptor (TLR) 9 ligand CpG has been used successfully for the immunotherapy of cancer. Chronic CpG application in tumor-free hosts leads, however, to the expansion of myeloid-derived suppressor cells (MDSC), which can cause T-cell suppression and may thus hamper the development of an effective immune response. Here, we investigated the effect of TLR9 activation on the fun...
متن کاملA new mechanism for blocking myeloid-derived suppressor cells by CpG.
In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.
متن کاملAntitumor effects of anti-CD40/CpG immunotherapy combined with gemcitabine or 5- fluorouracil chemotherapy in the B16 melanoma model
Our previous studies demonstrated that anti-CD40 mAb (anti-CD40) can synergize with CpG oligodeoxynucleotides (CpG) to mediate antitumor effects by activating myeloid cells, such as macrophages in tumor-bearing mice. Separate teams have shown that chemotherapy with gemcitabine (GEM) or 5-fluorouracil (5-FU) can reduce tumor-induced myeloid-derived suppressor cells (MDSC) in mice. In this study ...
متن کاملTumor-induced CD11b+Gr-1+ myeloid cells suppress T cell sensitization in tumor-draining lymph nodes.
Suppression of tumor-specific T cell sensitization is a predominant mechanism of tumor escape. To identify tumor-induced suppressor cells, we transferred spleen cells from mice bearing progressive MCA205 sarcoma into sublethally irradiated mice. These mice were then inoculated subdermally with tumor cells to stimulate T cell response in the tumor-draining lymph-node (TDLN). Tumor progression in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011